Gang Pei - The Consciousness Library

A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox.

Psychedelic LSD activates neurotrophic signal but fails to stimulate neural stem cells.

Stem cell research & therapy September 11, 2024 Xiaoxu Dong, He Lin, Yuting Li et al. 1 citation

Accumulating evidence has shown that some hallucinogens, such as LSD, have fast and persistent effects on anxiety and depression. According to a proposed mechanism, LSD activates the TrkB and HTR2A signaling pathways, which enhance the density of neuronal dendritic spines and synaptic function, and thus promote brain function. Moreover, TrkB signaling is also known to be crucial for neural stem...

DOI: 10.1186/s13287-024-03909-8 Full text LSD Psychedelics hallucinogens Entheogens Neuroscience brain science +7

Papers

A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox.

Psychedelic LSD activates neurotrophic signal but fails to stimulate neural stem cells.