A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox.
Cell Discov May 29, 2026 DOI: 10.1038/s41421-026-00906-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Key points | Proposes that psilocybin's paradoxical activation of both 5-HT₂A and TrkB receptors is reconciled by a spatiotemporal gating mechanism that coordinates their signaling to produce neuroplasticity. |
Abstract
A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox.