Neuroscience and Biobehavioral Reviews
May 1, 2026
Esmaeel G Gojani, Houman Farzin, Robert J Sutherland et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau pathology, synaptic dysfunction, and neuroinflammation, which collectively drive progressive memory loss, cognitive decline, and behavioral changes. Increasing evidence implicates epigenetic dysregulation as a key contributor to these pathological processes by altering gene...
European Journal of Neuroscience
October 4, 2024
Victorita E. Ivan, David P Tomàs-Cuesta, Ingrid M. Esteves et al.
4 citations
Abstract Psychedelic drugs have profound effects on perception, cognition and mood. How psychedelics affect neural signaling to produce these effects remains poorly understood. We investigated the effect of the classic psychedelic psilocybin on neural activity patterns and spatial encoding in the retrosplenial cortex of head‐fixed mice navigating on a treadmill. The place specificity of neurons...
April 22, 2024
Victorita E. Ivan, David P Tomàs-Cuesta, Ingrid M. Esteves et al.
1 citation
Psychedelic drugs have profound effects on perception, cognition, and mood. How psychedelics affect neural signaling to produce these effects remains poorly understood. We investigated the effect of the classic psychedelic psilocybin on neural activity patterns and spatial encoding in the retrosplenial cortex of head-fixed mice navigating on a treadmill. The place specificity of neurons to...
Biological Psychiatry Global Open Science
2024
Victorita E. Ivan, David P Tomàs-Cuesta, Ingrid M. Esteves et al.
7 citations
The ability of psychedelic compounds to profoundly alter mental function has been long known, but the underlying changes in cellular-level information encoding remain poorly understood. We used two-photon microscopy to record from the retrosplenial cortex in head-fixed mice running on a treadmill before and after injection of the nonclassic psychedelic ibogaine (40 mg/kg intraperitoneally). We...