Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression
The British Journal of Psychiatry December 5, 2024 Emma S Høgsted, Vincent Beliveau, Brice Ozenne et al. 4 citations
Background Using [ 18 F]altanserin, a serotonin 2A receptor (5-HT 2A R) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HT 2A R binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HT 2A R agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms...
DOI: 10.1192/bjp.2024.143 (opens in new tab)
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Personality research
Neuroimaging
Serotonin 2a receptor
Cortisol
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