Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression
The British Journal of Psychiatry December 5, 2024 Emma S Høgsted, Vincent Beliveau, Brice Ozenne et al. 4 citations
Background Using [ 18 F]altanserin, a serotonin 2A receptor (5-HT 2A R) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HT 2A R binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HT 2A R agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms...