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Abhishek Gupta

3 papers in the library · 1 citation · publishing 2025-2026

Papers

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Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects

ACS Pharmacology & Translational Science April 14, 2026 Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar et al.

The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often cause severe psychedelic effects due to differential binding to various brain receptors and cardiotoxicity by blocking the human ether-a-go-go-related gene...

Psychoactive substance use among medical and paramedical undergraduate students of Lucknow.

Journal of Education and Health Promotion 2025 Hariom Singh, Shivendra K Singh, Manish K Manar et al. 1 citation

Psychoactive drugs are substances that, when taken in or administered into one's system, affect mental processes like perception, consciousness, cognition, mood, and emotions. The use of psychoactive substances often starts at a young age. This study aimed to estimate the prevalence of psychoactive substance use among medical and paramedical undergraduate students of Lucknow. A cross-sectional...

Development of Bioisosteric Iboga -alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects

Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar et al. preprint

Abstract The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often cause severe hallucinogenic effects due to differential binding to various brain receptors and cardiotoxicity by blocking the human...