Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects
ACS Pharmacology & Translational Science April 14, 2026 Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar et al.
The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often cause severe psychedelic effects due to differential binding to various brain receptors and cardiotoxicity by blocking the human ether-a-go-go-related gene...
DOI: 10.1021/acsptsci.5c00301 (opens in new tab)
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Neuroprotection
Anxiolytic
Nociception
Analgesic
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