Jian Kong

2 papers in the library · 319 citations · publishing 2012-2013

Papers

Default mode network connectivity encodes clinical pain: An arterial spin labeling study

Pain October 29, 2012 Marco L. Loggia, Jieun Kim, Randy L. Gollub et al. 319 citations

Patients with chronic low back pain show stronger resting connectivity between the default mode network and the right insula, pregenual anterior cingulate cortex, and left inferior parietal lobule compared to healthy controls. Baseline clinical pain correlates positively with default mode network–right insula connectivity. Physical maneuvers that exacerbate pain produce parallel changes in default mode network–right insula connectivity and disrupt default mode network–pregenual anterior cingulate cortex connectivity, which at baseline was anticorrelated with pain. Baseline default mode network connectivity also predicts maneuver-induced changes in both pain and default mode network–right insula connectivity. These findings support resting default mode network connectivity as a potential neuroimaging biomarker for chronic pain perception.

DOI: 10.1016/j.pain.2012.07.029 Default mode network Insula Resting State FMRI Chronic pain +6

Meditation's impact on default mode network and hippocampus in mild cognitive impairment: a pilot study.

Neuroscience Letters November 27, 2013 Rebecca Erwin Wells, Gloria Y Yeh, Catherine E. Kerr et al.

In adults with mild cognitive impairment (MCI), an 8-week Mindfulness Based Stress Reduction (MBSR) program increased functional connectivity between the posterior cingulate cortex and both the medial prefrontal cortex and hippocampus, and showed trends of reduced hippocampal atrophy compared to usual care. These preliminary results suggest MBSR may positively affect brain regions linked to MCI and Alzheimer's disease, though larger studies with longer follow-up are needed.

DOI: 10.1016/j.neulet.2013.10.001 Full text Dmn Default mode network Mbsr Meditation +17