Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue.
Neuropeptides June 1, 1985 K A Clarke, A J Parker, G C Stirk 39 citations
Motoneurone field potentials have been recorded from the lumbar region of the spinal cord, to antidromic stimulation of a ventral root, in rats anaesthetised with urethane. Injection of the thyrotropin releasing hormone (TRH) analogue RX77368 (1mg/kg) plus the 5-hydroxytryptamine (5-HT) receptor agonist 5-methoxy-N, N-dimethyl-tryptamine (5MeODMT 0.4mg/kg) resulted in a potentiation of the...