Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine.
European Journal of Pharmacology March 3, 1987 Toshitaka Nabeshima, H Fukaya, K Yamaguchi et al. 70 citations
In rats treated with phencyclidine (PCP) repeatedly (PCP 10 mg/kg per day for 14 days), the back-pedalling, head-weaving and turning induced by PCP were attenuated (tolerance), while PCP-induced sniffing, rearing and ambulation were potentiated (supersensitivity). The behavior induced by the direct and indirect serotonin (5-HT) agonists, 5-methoxy-N,N-dimethyltryptamine and p-chloroamphetamine,...