Effects of repeated phencyclidine treatment on serotonin transporter in rat brain.
Neuroscience Letters February 11, 2000 T Hori, S Abe, A Baba et al.
Phencyclidine (PCP) is known to be an inhibitor of serotonin (5-HT) uptake and to increase serotonergic activity. The development of tolerance to serotonergic stereotyped behaviors induced by repeated PCP treatment and changes of 5-HT transporters were examined. Backpedalling was significantly reduced in frequency following 14 days PCP treatment (7.5 mg/kg per day). Furthermore, repeated PCP...