Ibogaine and the dopaminergic response to nicotine.
Psychopharmacology February 1, 1997 Isabelle M Maisonneuve, G L Mann, C R Deibel et al. 38 citations
There is increasing evidence that the rewarding effect of nicotine is mediated by the mesolimbic dopamine system. The first objective of this study was to examine the dopamine response to repeated i.v. infusions of nicotine. Using in vivo microdialysis in awake and freely moving male Sprague-Dawley rats, we demonstrated that i.v. nicotine infusions (0.16 mg/kg or 0.32 mg/kg per infusion)...