Marta Bassi

The MDPV Derivative α-PHP Regulates Cellular Differentiation and Triggers Apoptotic Cell Death and Ultrastructural Changes in Murine 3D Neurospheres

Molecules July 13, 2026 Fabrizio De Luca, Cinzia Brenna, Marta Bassi et al.

Cumulative reports of psychiatric and neurological outcomes due to synthetic cathinones continue to raise public concern. However, the understanding of the neurotoxic mechanism of action is still poorly understood, particularly for the under-explored αPHP, one of the main MDPV derivatives. In particular, the effects of this synthetic drug on neural stem/progenitor cell cultures are still...

DOI: 10.3390/molecules31142453 (opens in new tab) Neurosphere Apoptosis Programmed cell death Neural stem cell +14

Repeated administration of the synthetic cannabinoid AKB48 induces serotonergic neuroadaptation in male and female mice: behavioural and immunohistochemical evidence.

Neuropharmacology February 1, 2026 Giorgia Corli, Fabrizio De Luca, Sabrine Bilel et al. 1 citation

In the last years, Synthetic Cannabinoids (SCBs) have established themselves as one of the largest and most popular groups of Novel Psychoactive Substances (NPS), being frequently detected in biological samples of patients involved in intoxication and death cases. To date, compelling evidence on the potential interaction between SCBs and non-cannabinoid neurotransmission systems has emerged,...

DOI: 10.1016/j.neuropharm.2025.110758 (opens in new tab) Full text (opens in new tab) 25i-nbome pubchem cid 2c-i pubchem cid 5-ht2a receptors Akb48 pubchem cid +5

3-CMC: Acute Effects in Male and Female Mice, Human Intoxication Case Series (Italy, 2014–2025), and Prediction of ADMET Properties

International Journal of Molecular Sciences November 29, 2025 Marta Bassi, Elisa Roda, Giorgia Corli et al.

3-chloromethcathinone (3-CMC) is a synthetic cathinone that gained relevance, having been involved in a large number of seizures and poisoning reports. Despite this, literature currently lacks information on its pharmaco-toxicological effects. This study aims to investigate the acute sensorimotor and physiological effects of 3-CMC (0.1-30 mg/kg; i.p.) in male and female CD-1 mice and its...

DOI: 10.3390/ijms262311600 (opens in new tab) Cardiotoxicity Prepulse inhibition Psychomotor learning Acute toxicity +4

Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.

International Journal of Molecular Sciences March 20, 2025 Sabrine Bilel, Cristina Miliano, Giorgia Corli et al. 3 citations

25I-NBOMe (4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl) phenethylamine) is a synthetic psychedelic compound abused for its ambiguous legal state as a counterfeit lysergic acid diethylamide (LSD). 25I-NBOMe acts as a selective agonist of 5HT2A receptors leading to hallucinations, intoxications, and fatalities. Here, we assessed the rewarding properties of 25I-NBOMe and its behavioral and neurotoxic...

DOI: 10.3390/ijms26062815 (opens in new tab) Full text (opens in new tab) Synaptic plasticity 25i-nbome 5ht2a agonist Ltd +8

Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice-from a human poisoning case to the preclinical evidence.

Psychopharmacology March 1, 2024 Marta Bassi, Sabrine Bilel, Micaela Tirri et al. 7 citations

The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as "Moxy") is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly well-known; however, only few information is available regarding its pharmaco-toxicological effects. Following the seizure of this new psychoactive substances by the Arm of Carabinieri and...

DOI: 10.1007/s00213-024-06526-8 (opens in new tab) Full text (opens in new tab) 5-MEO-Mipt Admet prediction Behaviour Cardiorespiratory changes +11