GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse.
Proceedings of the National Academy of Sciences of the United States of America June 10, 2008 Sebastien Carnicella, Viktor Kharazia, Jérôme Jeanblanc et al. 132 citations
Previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell line-derived neurotrophic factor (GDNF) in the ventral tegmental area (VTA). Here we set out to test the actions of GDNF in the VTA on ethanol-drinking behaviors. We found that GDNF infusion very rapidly and dose-dependently reduced rat ethanol,...