Nature
2021
Lindsay P. Cameron, Robert J Tombari, Ju Lu et al.
468 citations
The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals1. Unlike most medications for the treatment of substance use disorders, anecdotal reports suggest that ibogaine has the potential to treat addiction to various substances, including opiates, alcohol and psychostimulants. The effects of ibogaine-like those of other psychedelic compounds-are long-lasting2,...
Addiction Biology
October 1, 2010
Sebastien Carnicella, Dao‐yao He, Quinn V Yowell et al.
49 citations
Ibogaine is a naturally occurring alkaloid that has been reported to decrease various adverse phenotypes associated with exposure to drugs of abuse and alcohol in human and rodent models. Unfortunately, ibogaine cannot be used as a medication to treat addiction because of severe side effects. Previously, we reported that the desirable actions of ibogaine to reduce self-administration of, and...
Proceedings of the National Academy of Sciences of the United States of America
June 10, 2008
Sebastien Carnicella, Viktor Kharazia, Jérôme Jeanblanc et al.
132 citations
Previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell line-derived neurotrophic factor (GDNF) in the ventral tegmental area (VTA). Here we set out to test the actions of GDNF in the VTA on ethanol-drinking behaviors. We found that GDNF infusion very rapidly and dose-dependently reduced rat ethanol,...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
November 1, 2006
Dao‐yao He, Dorit Ron, Dao‐yao He et al.
67 citations
We recently showed that the up-regulation of the glial cell line-derived neurotrophic factor (GDNF) pathway in the midbrain, is the molecular mechanism by which the putative anti-addiction drug Ibogaine mediates its desirable action of reducing alcohol consumption. Human reports and studies in rodents have shown that a single administration of Ibogaine results in a long-lasting reduction of...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
November 1, 2006
Dao‐yao He, Dorit Ron, Dao‐yao He et al.
67 citations
We recently showed that the up-regulation of the glial cell line-derived neurotrophic factor (GDNF) pathway in the midbrain, is the molecular mechanism by which the putative anti-addiction drug Ibogaine mediates its desirable action of reducing alcohol consumption. Human reports and studies in rodents have shown that a single administration of Ibogaine results in a long-lasting reduction of...
Journal of Neuroscience
January 19, 2005
Dao‐yao He, Nancy N. H. Mcgough, Ajay Ravindranathan et al.
181 citations
Alcohol addiction manifests as uncontrolled drinking despite negative consequences. Few medications are available to treat the disorder. Anecdotal reports suggest that ibogaine, a natural alkaloid, reverses behaviors associated with addiction including alcoholism; however, because of side effects, ibogaine is not used clinically. In this study, we first characterized the actions of ibogaine on...