John A Allen

2 papers in the library · 81 citations · publishing 2008-2009

Papers

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Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.

Biochemistry July 28, 2009 Feng Yan, Ruslan V Bikbulatov, Viorel Mocanu et al. 81 citations

Salvinorin A, the most potent naturally occurring hallucinogen, has attracted an increasing amount of attention since the kappa-opioid receptor (KOR) was identified as its principal molecular target by us [Roth, B. L., et al. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11934-11939]. Here we report the design, synthesis, and biochemical characterization of novel, irreversible, salvinorin A-derived...

DOI: 10.1021/bi900605n Full text Salvinorin a Kappa-opioid receptor Kor Receptor binding +17

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases.

Neuropharmacology July 2, 2008 John A Allen, Prem N. Yadav, Bryan L. Roth

5-HT(2A) serotonin receptors are essential molecular targets for the actions of LSD-like hallucinogens and atypical antipsychotic drugs. 5-HT(2A) serotonin receptors also mediate a variety of physiological processes in peripheral and central nervous systems including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. Scaffolding proteins have emerged as...

DOI: 10.1016/j.neuropharm.2008.06.048 Full text Animals Humans Arrestin Receptor, serotonin, 5-ht2a +4