Benjamín Rodríguez

2 papers in the library · 44 citations · publishing 2008-2009

Papers

Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of Opioid Receptor affinity.

Tetrahedron December 20, 2008 Gianfranco Fontana, Giuseppe Savona, Benjamín Rodríguez et al. 32 citations

Salvinorin A, a compound from the hallucinogenic mint Salvia divinorum, is the only known non-nitrogenous and specific kappa-opioid agonist. Several related compounds from Salvia splendens and a series of semisynthetic derivatives, including some with a pyrazoline structural moiety, were tested for their ability to bind to human mu, delta, and kappa opioid receptors. None of these compounds showed high-affinity binding to these receptors. However, one compound (10) showed modest affinity for kappa receptors, suggesting that other naturally occurring neoclerodanes from different Salvia species may have opioid affinity.

DOI: 10.1016/j.tet.2008.08.043 Full text Salvia divinorum Salvia splendens Salvia family Salvia genus +16

Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A.

Tetrahedron February 21, 2009 Gianfranco Fontana, Giuseppe Savona, Benjamín Rodríguez et al. 12 citations

Salvinorin A is a unique naturally occurring compound that activates κ-opioid receptors without containing nitrogen. Researchers modified the A ring of salvinorin A and related compounds from Salvia splendens and a non-natural derivative, producing new molecules. When tested for opioid receptor activity, none of these derivatives were active. The absence of activity may be due to the presence of a lactone group at specific positions in the molecular structure.

DOI: 10.1016/j.tet.2008.12.009 Full text Salvinorin a Salvia splendens Chemical synthesis Opioid receptor activity