Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.
Bioorganic & Medicinal Chemistry Letters May 15, 2013 Prabhakar R Polepally, Kate White, Eyal Vardy et al. 24 citations
Salvinorin A, the active ingredient of the hallucinogenic plant Salvia divinorum is the most potent known naturally occurring hallucinogen and is a selective κ-opioid receptor agonist. To better understand the ligand-receptor interactions, a series of dicarboxylic ester-type of salvinorin A derivatives were synthesized and evaluated for their binding affinity at κ-, δ- and μ-opioid receptors....