Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice
Psychopharmacology December 9, 2010 Adam L. Halberstadt, Virginia Lehmann-Masten, Mark A. Geyer et al. 35 citations
RATIONALE: Metabotropic glutamate (mGlu) receptors have been suggested to play a role in neuropsychiatric disorders including schizophrenia, drug abuse, and depression. Because serotonergic hallucinogens increase glutamate release and mGlu receptors modulate the response to serotonin (5-HT)(2A) activation, the interactions between serotonin 5-HT(2A) receptors and mGlu receptors may prove to be...