Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents.
Journal of psychopharmacology (Oxford, England) July 1, 2016 Deborah C. Mash, Barbara Ameer, Delphine Prou et al. 29 citations
This study investigated the effects of noribogaine, the principal metabolite of the drug ibogaine, on substance-related disorders. In the first experiment, mice chronically treated with morphine were subjected to naloxone-precipitated withdrawal two hours after oral administration of noribogaine. Oral noribogaine dose dependently decreased the global opiate withdrawal score by up to 88% of...