Benjamin E Turk

Control of serotonin transporter phosphorylation by conformational state.

Proceedings of the National Academy of Sciences May 17, 2016 Yuan-Wei Zhang, Benjamin E Turk, Gary Rudnick 53 citations

Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Mutations in human SERT are associated with psychiatric disorders and autism. Some of these mutations affect the regulation of SERT activity by cGMP-dependent phosphorylation. Here we provide direct evidence that this...