Daniel Szöllősi

2 papers in the library · 18 citations · publishing 2016-2022

Papers

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(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice.

Neuropsychopharmacology March 1, 2022 Deborah Rudin, John D. Mccorvy, Grant C. Glatfelter et al. 18 citations

Derivatives of (2-aminopropyl)indole (API) and (2-aminopropyl)benzofuran (APB) are new psychoactive substances which produce stimulant effects in vivo. (2-Aminopropyl)benzo[β]thiophene (APBT) is a novel sulfur-based analog of API and APB that has not been pharmacologically characterized. In the current study, we assessed the pharmacological effects of six APBT positional isomers in vitro, and...

DOI: 10.1038/s41386-021-01221-0 Full text Psychedelics Neuropharmacology Therapeutic applications Drug discovery

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Journal of Biological Chemistry August 1, 2016 Ameya Kasture, Ali El-Kasaby, Daniel Szöllősi et al.

Folding-defective mutants of the human dopamine transporter (DAT) cause a syndrome of infantile dystonia/parkinsonism. Here, we provide a proof-of-principle that the folding deficit is amenable to correction in vivo by two means, the cognate DAT ligand noribogaine and the HSP70 inhibitor, pifithrin-μ. We examined the Drosophila melanogaster (d) mutant dDAT-G108Q, which leads to a sleepless...

DOI: 10.1074/jbc.m116.737551 Full text Ibogaine Animals Humans Drosophila melanogaster +11