Birgit Schiøtt

2 papers in the library · 20 citations · publishing 2016-2019

Papers

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Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies.

Neuropharmacology December 15, 2019 Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning et al. 20 citations

The serotonin transporter (SERT) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. SERT is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. Dysregulation of SERT has been implicated in several major psychiatric disorders such as major depressive...

DOI: 10.1016/j.neuropharm.2019.02.030 Full text Leut Monoamine transporters Mutagenesis X-ray crystallography +8

Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations.

PLoS One June 14, 2016 Heidi Koldsø, Henriette Elisabeth Autzen, Julie Grouleff et al.

The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing conformation, while the non-competitive inhibitor ibogaine, and its active metabolite noribogaine, have been proposed to induce an inward-facing...

DOI: 10.1371/journal.pone.0063635 Full text