Henriette Elisabeth Autzen

Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations.

PLoS One June 14, 2016 Heidi Koldsø, Henriette Elisabeth Autzen, Julie Grouleff et al.

The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing conformation, while the non-competitive inhibitor ibogaine, and its active metabolite noribogaine, have been proposed to induce an inward-facing...