Chemical syntheses of the salvinorin chemotype of KOR agonist.
Natural Product Reports November 18, 2020 Sarah J Hill, Aurélien U C M Brion, Ryan A Shenvi
Covering: 2000 to 2020 The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid receptor (KOR). Its unique attributes-lack of a basic nitrogen, rapid brain penetrance, short half-life-combined with the potential of KOR as an emerging target for analgesics have stimulated extensive medicinal chemistry based on semi-synthesis from extracts of Salvia...