Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview.
Journal of psychopharmacology (Oxford, England) December 1, 2023 Genís Ona, Ingrid Reverte, Giordano N. Rossi et al. 20 citations
Ibogaine and its main metabolite, noribogaine, modulate several brain targets associated with substance use disorders. Rather than having a single key mechanism, their anti-addictive action appears to arise from a complex modulation of multiple receptor systems, creating potential beneficial synergies. This understanding comes from a review of theoretical and experimental studies published up to July 2022. The authors suggest that future research should apply polypharmacology approaches to better describe the multifaceted patterns of this multi-target drug, which could guide both mechanistic and therapeutic studies.