Highlights What are the main findings? A HPLC-QTOF/MS system was used to detect potential metabolites of 2-FDCK and 2-FXE in rats, determine metabolic pathways, and analyze metabolic differences. After single intraperitoneal injection administration of the drugs, samples were collected at 1 h and 2 h post-dosing. Metabolites were identified through database searches and secondary mass...
This study investigated the metabolic profiles of two isomeric psychoactive agents, methyl-ketamine [2-(ortho-tolyl)-2-(methylamino)cyclohexanone] and 2-oxo-PCE [2-(phenyl)-2-(ethylamino)cyclohexanone], in rats. Following oral administration, blood, liver, and urine samples were collected at timed intervals and analyzed via ultrahigh performance liquid chromatography quadrupole time-of-flight...