Altered excitation-inhibition balance in the somatomotor and default mode network in multiple sclerosis
medRxiv Preprint Server January 14, 2026 Gaia Zin, Guy Nagels, Jeroen Van Schependom et al. preprint
Introduction The balance between excitatory and inhibitory (E/I) neural processes is a fundamental principle of brain function, and its disruption has been implicated in the pathophysiology of multiple sclerosis (MS). In vivo assessment of E/I balance has traditionally relied on electrophysiological measures, and despite the abundance of fMRI data on MS, no fMRI-based technique has so far been...