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Grace O'Regan

2 papers in the library · 5 citations · publishing 2025-2026

Papers

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Delayed psilocybin treatment after repeated mild traumatic brain injury recovers chronic behavioural deficits, reduces microglial density, and enhances hippocampal neurogenesis in rats

Research Square February 23, 2026 Sandy R Shultz, Josh Allen, Grace O'Regan et al.

Abstract Repeated mild traumatic brain injury (RmTBI) can produce lasting cognitive, emotional, and social deficits (e.g., persistent post-concussion symptoms; PPCS). Despite the prevalence of RmTBI in sports, military, and domestic violence settings, effective treatments to alleviate the neurological consequences of RmTBI remain limited. Psilocybin, a serotonergic psychedelic, can enhance...

Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?

Neurobiology of Stress May 1, 2025 Alanna Kit, Kate Conway, Savannah Makarowski et al. 5 citations

There is growing interest in exploring the therapeutic potential and mechanisms of action of psilocybin on stress-related neuropsychiatric disorders, including depression, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), addiction, and disordered eating. Despite promising progressions in preclinical and clinical research, the...