Harnessing neuroplasticity with psychoplastogens: the essential role of psychotherapy in psychedelic treatment optimization.
Front Psychiatry April 8, 2025 Jennifer L. Jones 5 citations
Psychedelic-assisted therapy may be optimized by integrating psychotherapy with the administration of psychoplastogens—substances that promote neuroplasticity. The authors argue that the therapeutic context and psychological support are essential for translating neurobiological changes into lasting mental health improvements. They suggest that without structured psychotherapy, the neuroplastic effects of psychedelics alone are insufficient for sustained clinical benefit. The paper emphasizes the need for careful treatment design that combines pharmacological and psychotherapeutic interventions to maximize outcomes.