Harnessing neuroplasticity with psychoplastogens: the essential role of psychotherapy in psychedelic treatment optimization.
Front Psychiatry April 8, 2025 DOI: 10.3389/fpsyt.2025.1565852 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractPsychedelic-assisted therapy may be optimized by integrating psychotherapy with the administration of psychoplastogens—substances that promote neuroplasticity. The authors argue that the therapeutic context and psychological support are essential for translating neurobiological changes into lasting mental health improvements. They suggest that without structured psychotherapy, the neuroplastic effects of psychedelics alone are insufficient for sustained clinical benefit. The paper emphasizes the need for careful treatment design that combines pharmacological and psychotherapeutic interventions to maximize outcomes.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Neuroplasticity Psychedelic-assisted therapy |
| Keywords | Mental health treatment Psychotherapy integration Therapeutic support |
| Citations | 5 |
| Key finding | Argues that psychotherapy is essential for optimizing psychedelic treatment by harnessing neuroplasticity. |
Abstract
Harnessing neuroplasticity with psychoplastogens: the essential role of psychotherapy in psychedelic treatment optimization.