Schizophrenia Bulletin
December 14, 2025
Stjepan Curic, Moritz Haaf, Darius Zokai et al.
Pre-attentive information processing deficits are associated with poor outcomes in schizophrenia. The auditory mismatch negativity (MMN), observed when an auditory signal changes, is reduced in schizophrenia, related to glutamatergic dysfunction and is considered a response biomarker. We hypothesized that glycine, an N-methyl-d-aspartate receptor (NMDAR) coagonist, could reverse the...
Frontiers in Pharmacology
2025
Denise Elfriede Liesa Lockhofen, Nils Hübner, Ranjan Debnath et al.
2 citations
Patients with schizophrenia frequently experience inadequate attribution of motivational salience, possibly related to impaired attentional processing and dysfunctional reward learning. According to the "glutamate hypothesis of schizophrenia", glutamatergic dysregulations can contribute to the emergence of psychotic symptoms and cognitive deficits in patients with schizophrenia. Blocking the...
bioRxiv Preprint Server
April 15, 2021
Moritz Haaf, Stjepan Curic, Saskia Steinmann et al.
preprint
Although a substantial number of studies suggests some clinical benefit concerning negative symptoms in schizophrenia through the modulation of NMDA-receptor function, none of these approaches achieved clinical approval. Given the large body of evidence concerning glutamatergic dysfunction in a subgroup of patients, biomarkers to identify those with a relevant clinical benefit through...
Neuropsychopharmacology
February 6, 2019
Stjepan Curic, Gregor Leicht, S. Thiebes et al.
Abnormal gamma-band oscillations (GBO) have been frequently associated with the pathophysiology of schizophrenia. GBO are modulated by glutamate, a neurotransmitter, which is continuously discussed to shape the complex symptom spectrum in schizophrenia. The current study examined the effects of ketamine, a glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist, on the auditory-evoked...