Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine
medRxiv Preprint Server June 28, 2023 Mohammad Ali Shenasa, Houtan Totonchi Afshar, Eric A. Miller et al. preprint
Background The antidepressant effects of ketamine and repetitive transcranial magnetic stimulation (rTMS) are hypothesized to rely on mechanisms of long-term-potentiation and synaptic plasticity. Cannabis, via activation of CB1 receptors has been shown to impair synaptic plasticity, suggesting that cannabis use might moderate the antidepressant effects of ketamine and/or rTMS.