Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine
Mohammad Ali Shenasa, Houtan Totonchi Afshar, Eric A. Miller, Em Ellerman-Tayag, Jyoti Mishra, Dhakshin Ramanathan
medRxiv Preprint Server June 28, 2023 preprint DOI: 10.1101/2023.06.28.23291446 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | Cannabis Esketamine Ketamine |
| Keywords | Cannabis use Substance use Depression treatment Depression therapy Antidepressant therapy Brain therapies Ketamine therapy Rtms Transcranial magnetic stimulation Neuromodulation Mental health Well-being |
| Key points | Proposes that cannabis use may moderate the antidepressant effects of ketamine and rTMS by impairing synaptic plasticity via CB1 receptor activation. |
Abstract
Background The antidepressant effects of ketamine and repetitive transcranial magnetic stimulation (rTMS) are hypothesized to rely on mechanisms of long-term-potentiation and synaptic plasticity. Cannabis, via activation of CB1 receptors has been shown to impair synaptic plasticity, suggesting that cannabis use might moderate the antidepressant effects of ketamine and/or rTMS.