Psychedelics and the Gut Microbiome: Unraveling the Interplay and Therapeutic Implications.
ACS Chemical Neuroscience July 9, 2025 Xue Wang, Fan Jun, Cong Lin et al. 4 citations
Classic psychedelics and the gut microbiome interact bidirectionally through mechanisms involving 5-HT2A receptor signaling, neuroplasticity, and microbial metabolism. This viewpoint highlights how psychedelics may reshape microbiota and how microbes influence psychedelic efficacy, proposing microbiome-informed strategies─such as probiotics or dietary interventions─to personalize and enhance...