Marnix J. Sigtermans

S(+)-ketamine Effect on Experimental Pain and Cardiac Output

Anesthesiology September 18, 2009 Marnix J. Sigtermans, Albert Dahan, René A. G. Mooren et al. 152 citations

BACKGROUND: Low-dose ketamine behaves as an analgesic in the treatment of acute and chronic pain. To further understand ketamine's therapeutic profile, the authors performed a population pharmacokinetic-pharmacodynamic analysis of the S(+)-ketamine analgesic and nonanalgesic effects in healthy volunteers. METHODS: Ten men and ten women received a 2-h S(+)-ketamine infusion. The infusion was...