Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex.
Psychopharmacology December 2005 Paul J Fletcher, Catherine C Tenn, Zoë Rizos et al.
Repeated exposure to psychomotor stimulants can lead to sensitization to their effects, and sensitization has been implicated in the pathophysiology of schizophrenia and drug abuse. These disorders are characterized by cognitive deficits, particularly in prefrontally mediated executive function. The present experiments were conducted to investigate the effects of sensitizing regimens of...