Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003 Andrea Balla, Henry Sershen, Michael Serra et al.
Functional dopaminergic hyperactivity is a key feature of schizophrenia. Etiology of this dopaminergic hyperactivity, however, is unknown. We have recently demonstrated that subchronic phencyclidine (PCP) treatment in rodents induces striatal dopaminergic hyperactivity similar to that observed in schizophrenia. The present study investigates the ability of PCP to potentiate amphetamine-induced...