Downregulation of 5-hydroxytryptamine7 receptor in the medial prefrontal cortex ameliorates impulsive actions in animal models of schizophrenia.
Behavioural Brain Research April 2, 2018 Wei Zhang, Junhui Liu, Jinteng Feng et al.
R mRNA in the mPFC was significantly decreased to 5-Hydroxytryptamine7 (5-HT7) receptors in the medial prefrontal cortex (mPFC) play a critical role in complex cognitive impairment in schizophrenia. The mouse model of schizophrenia was established through the neonatal administration of phencyclidine (nPCP). Recombinant adeno-associated virus-mediated gene knockdown was used to investigate the...
DOI: 10.1016/j.bbr.2017.12.023 (opens in new tab)
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Impulsivity
Medial prefrontal cortex
Phencyclidine
Schizophrenia