Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Psychopharmacology September 2007 Nurith Amitai, Svetlana Semenova, Athina Markou
Cognitive deficits in schizophrenia are severe and do not respond well to available treatments. The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits. We investigated whether single and repeated administrations of the psychotomimetic...