Experience with dronabinol consumption facilitated a stimulant effect of alcohol and affected alcohol-related changes in frontal cortical endocannabinoid levels in male rats.
Behavioural Brain Research August 24, 2023 Daniel T Sangiamo, Michael J Weingarten, Nnamdi G Nelson et al.
Combined use of cannabis and alcohol is common in adolescents. However, the extent to which such polydrug exposure affects the brain and behaviors remains under-investigated in preclinical studies. This study tested the hypothesis that combined exposure of Δ-9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, and alcohol will have additive effects on cognitive...
DOI: 10.1016/j.bbr.2023.114587 (opens in new tab)
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Adolescence
Alcohol
Barnes maze
Endocannabinoids
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