Jessica Mitchell

Bupropion-Memantine Combination in the Treatment of Major Depressive Disorder and Treatment-Resistant Depression.

Human psychopharmacology May 2026 Juan Miguel Riestra, Yaxel Levin-Carrion, Roshan Sutar et al.

Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments. Pathophysiology in MDD has highlighted the N-methyl-D-aspartate (NMDA) glutamatergic system as a promising therapeutic target. In 2022, the US Food and Drug Administration...