Ken-ichiro Kubo

GABAergic precursor transplantation into the prefrontal cortex prevents phencyclidine-induced cognitive deficits.

Journal of Neuroscience October 5, 2011 Daisuke H. Tanaka, Kazuya Toriumi, Ken-ichiro Kubo et al.

Phencyclidine (PCP) is a noncompetitive NMDA receptor antagonist, and it induces schizophreniform cognitive deficits in healthy humans and similar cognitive deficits in rodents. Although the PCP-induced cognitive deficits appear to be accompanied and possibly caused by dysfunction of GABAergic inhibitory interneurons in the prefrontal cortex (PFC), the potential benefit(s) of GABAergic...