Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats.
Cerebral Cortex September 2014 Celia Kjærby, Brian V Broberg, Uffe Kristiansen et al.
A compromised γ-aminobutyric acid (GABA)ergic system is hypothesized to be part of the underlying pathophysiology of schizophrenia. N-methyl-D-aspartate (NMDA) receptor hypofunction during neurodevelopment is proposed to disrupt maturation of interneurons causing an impaired GABAergic transmission in adulthood. The present study examines prefrontal GABAergic transmission in adult rats...
DOI: 10.1093/cercor/bht109 (opens in new tab)
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Nmda receptor antagonist
Development
Electrophysiology
Frontal cortex
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