Baseline temperature in an animal model of schizophrenia: long-term effects of perinatal phencyclidine administration.
Physiology & Behavior February 27, 2008 Nevena V Radonjić, Nataša Petronijević, Sonja Vučković et al.
Phencyclidine (PCP), a dissociative anaesthetic, acts as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. PCP is a psychostimulant capable of producing both positive and negative symptoms of schizophrenia, including cognitive dysfunction in normal humans. Perinatal phencyclidine administration to rats has been widely accepted as an animal model of schizophrenia. It has been...