Li-Wen He

Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration.

European Journal of Pharmacology May 1, 2004 Christopher J Pace, Stanley D Glick, Isabelle M Maisonneuve et al.

18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4 acetylcholine receptors. In an attempt to identify more potent 18-methoxycoronaridine analogs, we have tested a series of 18-methoxycoronaridine...