A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration.
Frontiers in Systems Neuroscience 2009 Michael C. Quirk, Dara L Sosulski, Claudia E Feierstein et al.
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons...
DOI: 10.3389/neuro.06.013.2009 (opens in new tab)
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Depression
Fast-spiking interneuron
Motivation
Parvalbumin
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