Indolethylamine‐N MethylTransferase (INMT) is a small molecule N‐methyltransferase that transfer methyl groups from S‐Adenosyl‐L‐Methionine (SAM) to indoleamines. Methylation of tryptamine produces the hallucinogen, N,N‐dimethyltryptamine (DMT), and methylated serotonin generates bufotenin. In animals, the endogenous production of DMT has been proposed to be a regulator of the Sigma‐1 Receptor...
BiochemistryMay 13, 2014Uyen B Chu, Sevahn K Vorperian, Kenneth Satyshur et al.
Indolethylamine-N-methyltransferase (INMT) is a Class 1 transmethylation enzyme known for its production of N,N-dimethyltryptamine (DMT), a hallucinogen with affinity for various serotonergic, adrenergic, histaminergic, dopaminergic, and sigma-1 receptors. DMT is produced via the action of INMT on the endogenous substrates tryptamine and S-adenosyl-l-methionine (SAM). The biological,...
The function of the sigma-1 receptor (S1R) has been linked to modulating the activities of ion channels and G-protein-coupled receptors (GPCR). In the CNS, the S1R is expressed ubiquitously but is enriched in mouse motoneurons (MN), where it is localized to subsurface cisternae of cholinergic postsynaptic densities, also known as C-terminals. We found that S1R is enriched in mouse spinal MN at...