Nightmares are almost an ubiquitous phenomenon but only nightmare disorders would need to be treated. Nightmare disorders result from a variety of causes including posttraumatic stress disorder (PTSD), psychiatric disorders, substance abuse, or idiosyncrasy. Nightmare disorders can be treated by either pharmacotherapy or psychotherapy. We performed literature search to explore eighteen possible...
The function of the sigma-1 receptor (S1R) has been linked to modulating the activities of ion channels and G-protein-coupled receptors (GPCR). In the CNS, the S1R is expressed ubiquitously but is enriched in mouse motoneurons (MN), where it is localized to subsurface cisternae of cholinergic postsynaptic densities, also known as C-terminals. We found that S1R is enriched in mouse spinal MN at...