Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal.
Neurotoxicology December 2018 Roberta Monteiro Incrocci, Franciely Paliarin, Manoel Jorge Nobre
Ketamine (KET) is a non-competitive N-Methyl-d-aspartate (NMDA) receptors antagonist that intensifies sensory experiences, prompts hallucinations and delusions, exacerbates previously installed psychosis and disrupts physiological evoked potentials (AEPs). Pharmacologically, KET stimulates glutamate efflux in the medial prefrontal cortex, mainly in the prelimbic (PrL) sub-region. Efferences...
DOI: 10.1016/j.neuro.2018.08.013 (opens in new tab)
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Ketamine
Serotonin
Auditory evoked potentials
Behavior
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